Mark Lockwood, PhD, RN, CCRC

  • Asssistant Professor
Bio

I have spent a majority of my 20 year nursing career working as a clinical research nurse. I have had the honor of working with top researchers in the field of chronic kidney disease and solid organ transplantation including: Joel Copper, M.D., Daniel Brennan, M.D., J.R. Thistlethwaite, M.D, and Sandra Cupples, Ph.D., R.N. I have been educated in all aspects of conducting clinical research, the Code of Federal Regulations governing research in the United States, and the key concepts and principles related to Good Clinical Practice (GCP), and have been involved in the successful implementation of over 40 industry sponsored and/or investigator initiated clinical trials.

As the recipient of the 2013 Edith Anderson Education Leadership Award from The Honor Society of Nursing: Sigma Theta Tau International (STTI) and the 2013 & 2015 International Transplant Nurses Society (ITNS) Research Grant Awards, I have a proven track record of success in grant writing and obtaining competitive research awards. Since 2012, with the help of these funding agencies, I have successfully recruited and managed a multidisciplinary team of nurses, physicians, and outreach coordinators and overseen the completion of two cross-sectional studies and a prospective clinical trial cumulatively involving over 600 subjects. I have also begun to develop my reputation as a leader in nursing locally as evidenced by my election and service as the co-chair of the University of Chicago Evidence-based Practice and Research Council from 2013-2016, and internationally as evidenced by my recent election to the board of the ITNS as Director at Large.

Current Area of Teaching

NURS 516 EBP 2: Implementing Evidence-Based Practice

Selected Honors & Awards
  • 2017 Fellow, Summer Genetics Institute, National Institute of Nursing Research   
  • 2016  Service Excellence Award: University of Chicago Nursing EBP and Research Council
  • 2016-present  International Transplant Nurses Society Board of Directors:  Director at Large 
  • 2015  Semifinalist, Uchicago App Challenge, University of Chicago
  • 2011  Induction, The Honors Society of Nursing, Sigma Theta Tau International
  • 2011  Dean’s scholarship, Oregon Health and Science University School of Nursing
  • 2005  Certified Clinical Research Coordinator, Association of Clinical Research Professionals
  • 1997  President’s Service Excellence Award, Barnes-Jewish Hospital, St. Louis, MO
Selected Publications

Lockwood, M. B., Dunn-Lopez, K., Burke, L., Becker, Y. T., & Saunders, M. (2017). Frequency of In-Home Internet Use Among Prekidney and Postkidney Transplant Patients—Facilitators and Barriers to Use and Trends Over Time. Transplantation Direct, 3(11), e216. doi:10.1097/txd.0000000000000735

Lockwood MB, Saunders MR, Nass R, McGivern CL, Cunningham PN, Chon WJ, et al. (2017) Patient-Reported Barriers to the Prekidney Transplant Evaluation in an At-Risk Population in the United States. Progress in transplantation (Aliso Viejo, Calif). 2017;27(2):131-8. Epub 2017/06/16. doi: 10.1177/1526924817699957. PubMed PMID: 28617167.

Lockwood, M.B., Bidwell, J., Werner, D., & Lee, C.S. (2016). Non-biological barriers to referral and the pre-kidney transplant evaluation among African Americans in the United States: A systematic review. Nephrology Nursing Journal, 43(3), 225-238.

Lockwood, M., Saunders, M., Josephson, M, Becker, Y., & Lee, C. (2015). Determinants of frequent Internet use in an urban kidney transplant population in the United States:  Characterizing the digital divide. Progress in Transplantation, 25(1), 1-9.

Lockwood, M.B., Saunders, M. Lee, C.S., Becker, Y.T., Josephson, M.A., and Chon, W.J., (2013). Renal Transplantation and the Digital Divide:  Does Information and Communication Technology Represent a Barrier or a Bridge to Transplantation for African Americans? Progress in Transplantation, 23(4), 302-9.  DOI: 10.7182/pit20113869.

Khoury JA, Storch GA, Bohl DL, Schuessler RM, Torrence SM, Lockwood MB, Gaudreault-Keener M, Koch MJ, Miller BW, Hardinger KL, Schnitzler MA, Brennan DC:  Prophylactic versus preemptive oral valganciclovir for the management of cytomegalovirus infection in adult renal transplant recipients.  American Journal of Transplantation, 2006; 6: 1-10.

Hardinger KL, Bohl D, Schnitzler MA, Lockwood MB, Storch GA, Brennan DC:  A randomized, pharmacoeconomics trial of tacrolimus versus cyclosporine in combination with Thymoglobulin in renal transplant recipients.  Transplantation, 2005; 80:  41-46.

Brennan DC, Agha I, Bohl DL, Schnitzler MA, Hardinger KL, Lockwood MB, Torrence S, Schuessler R, Roby T, Gaudreault-Keener M, Storch GA:  Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction.  Am J Transplant, 5:582-594, 2005.

Brennan DC, Hardinger KL, Bohl DL, Lockwood MB, Torrence Louis, MO,  J Am Soc Nephrol 15, Abstract SA-FC009 pp 23A, 2004.S, Schuessler R, Gaudreault M, Roby T, Koch MJ, Miller BW, Schnitzler MA, Storch GA:  Preemptive vs prophylactic valganciclovir for CMV in renal transplantation:  Early results from a randomized, prospective trial.  American Society of Nephrology 2004, St.

Current Research

My research program has four main components: 1) advancing symptom science through the identification of symptom clusters in patients with chronic kidney disease, 2) Exploring the effects of the gut microbiome on symptoms and adverse outcomes in pre-and post-kidney transplant recipients, 3) Continuing work understanding the nuances of information and communication technology use among patients with chronic illness, and 4) Reducing existing health disparities/inequities by developing of innovative strategies leveraging other areas of my research program.

My research program takes an ‘omics’ approach to medication adherence.  High patient symptom burden, including depression and anxiety-like symptoms have been linked to medication non-adherence among post-kidney transplant patients. In addition, there is a clear link between disruptions in the gut microbiome, also known as dysbiosis, and behavior via the brain-gut microbiome axis.  It is known that antibiotic, antivirals, and immunosuppressant medications alter the relative abundance of these beneficial bacteria.  We have begun work exploring relationships between disruptions in the oral/gut microbiota that result from exposure to antibiotics, immunosuppression, and stress from the transplant surgery, the patient’s symptom burden, and medication adherence in a prospective study of patients with end stage renal disease who progress to kidney transplantation. This work is being done in conjunction with Dr. Stefan Green and colleagues at the DNA Services Laboratory at UIC. Our research will compliment efforts that focus on behavioral, psychosocial, and environmental causes of medication non-adherence by exploring underlying biological mechanisms for non-adherence, including medication taking behaviors that may be linked to the brain-gut-microbiome axis.