Terri E. Weaver, PhD, RN, FAAN

  • Dean
  • Professor
Bio

Dr. Weaver is recognized nationally and internationally for her research on the effect of daytime sleepiness on daily behaviors and assessment of treatment outcomes. Her program of research centers on treatment adherence, analysis of treatment efficacy for obstructive sleep apnea, and mechanisms and outcomes of daytime sleepiness. She has expertise in issues related to functional status/quality of life, treatment adherence, instrument development, and randomized clinical trials.  Dr. Weaver has produced two notable disease specific functional status measures, one for chronic pulmonary disorders and the other for sleep disorders. The latter, the Functional Outcomes of Sleep Questionnaire has become the gold standard for the evaluation of the impact of impact of treatments for sleep disorders to improve quality of life, which has been translated into 51 languages and used internationally in clinical trials.  Her program of research centers on treatment adherence, analysis of treatment efficacy for obstructive sleep apnea, and mechanisms and outcomes of daytime sleepiness. Extending outcomes beyond physiological measures, Dr. Weaver has conducted multisite research to determine the appropriate duration of nasal continuous positive pressure treatment for obstructive sleep apnea required to normalize key behaviors such as functional status. Dr. Weaver and colleagues were the first to characterize the acute decline in adherence observed over the first week of nasal continuous positive airway pressure treatment for obstructive sleep apnea. This work was extended in a study designed to isolate factors contributing to this non-adherence, in which Dr. Weaver serves as the Principal Investigator. She also was the first to describe the dose-response relationship between hourly duration of CPAP use and normalization of salient clinical outcomes.  This research was the basis for the AASM recommendation that adherence to CPAP treatment be objectively monitored and use of this therapy should be monitored with appropriate intervention in the first week of treatment.  Dr. Weaver has completed the first and largest multisite randomized clinical trial evaluating the effectiveness of nasal continuous position airway pressure for milder sleep apnea.  Dr. Weaver’s research has been supported by the National Heart Blood and Lung Institute of the National Institutes of Health.

Selected Honors & Awards
  • Sigma Theta Tau International Honor Society of Nursing
  • Marion R. Gregory Award (for dissertation that holds significant promise as a contribution to nursing knowledge), University of Pennsylvania School of Nursing
  • Fellow, American Academy of Nursing
  • Outstanding Faculty Award, University of Pennsylvania Sorority and Fraternity System
  • Ada Sue Hinshaw Award, Friends of the National Institute of Nursing Research for research that focuses attention on the significance of nursing research and improves health care
  • Distinguished Alumni Award, University of Pittsburgh School of Nursing
  • Graduation Speaker University of Pittsburg Graduate Student Dinner
  • University of Pittsburgh School of Nursing Visiting Scholar
  • Fellow, Institute of Medicine of Chicago
Selected Publications
  • Weaver T E, Laizner A, Evans L K, Maislin G, Chugh DK, Lyons K, Smith PL, Schwartz AR, Redline S, Pack AI, Dinges DF.  An instrument to measure functional status outcomes for disorders of excessive sleepiness. Sleep,  20(10), 835 - 843, 1997. 
  • Weaver, TE, Narsavage GL, Guilfoyle MJ. The development and psychometric evaluation of the Pulmonary Functional Status Scale (PFSS): An instrument to assess functional status in pulmonary disease.  Journal of Cardiopulmonary Rehabilitation, 18, 105 – 111, 1998
  • Weaver TE, Kribbs NB, Pack AI, Kline LR, Chugh DK, Maislin G, Smith PL, Schwartz AR, Schubert NM, Gillen KA, Dinges DF. Night-to-night variability in CPAP use over first three months of treatment.  Sleep, 20, 278 - 283, 1997. 
  • Weaver, TE.  Outcome measurement in sleep medicine practice and research.  Part 1:  Assessment of OSA symptoms, subjective and objective daytime sleepiness, health - related quality of life, and functional status.  Sleep Medicine Review, 5, 103-128, 2001 (Invited) PMID: 12531049
  • Weaver, TE. Outcome measurement in sleep medicine practice and research.  Part 2: Assessment of neurobehavioral performance and mood.  Sleep Medicine Review, 5, 223-236, 2001 (Invited) 
  • Gooneratne, NS; Weaver, TE, Cater, JR; Pack FM, Arner HM, Greenberg AS, Pack AI. Functional outcomes of excessive daytime sleepiness in non-depressed older adults. Journal of the American Geriatric Society, 51,642-649, 2003  PMID:12752839
  • Weaver, TE., Maislin G, Dinges D, Younger J, Cantor C, McCloskey S, Pack A.  Self-efficacy in sleep apnea:  Instrument development and patient perceptions of OSA risk, treatment benefit, and volition to use CPAP. SLEEP, 26, 727-732, 2003
  • Dinges DF, Weaver, TE.  Modafinil improves sustained attention and quality of life in obstructive sleep apnea, Sleep Medicine 4, 393-402, 2003  PMID:14592280
  • Chasens ER, Pack AI, Maislin G, Dinges DF, Weaver, TE.  Claustrophobia and adherence to CPAP Treatment.  Western Journal of Nursing Research. 27, 307-321, 2005  PMID:15781905
  • Reishtein J, Pack AI, Maislin G, Dinges D, Bloxham T, George C, Kader G, Greenberg H, Mahowald M, Younger J, Weaver, TE, and Multisite Group. Sleepiness and relationships in obstructive sleep apnea. Issues in Mental Health Nursing. 27(3), 319-30, 2006  PMID:16484173
  • Gay P, Weaver, TE, Loube D, Iber C. Evaluation of positive airway pressure treatment for sleep-related breathing disorders in adults. SLEEP. 29(3), 381-401, 2006 PMID:16553025
  • Weaver, TE, Cuellar N.  A randomized trial evaluating the effectiveness of sodium oxybate therapy on quality of life in narcolepsy. SLEEP. 29 (9), 1189-1194, 2006  PMID:17040006
  • Weaver, TE.  CPAP Adherence.  Current Opinion in Pulmonary Medicine. 12 (6), 409-413, 2006 (Invited)  PMID:17053489
  • Weaver TE, Maislin G, Dinges DF, Bloxham T, George C, Greenberg H, et al. Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning. Sleep;30(6):711-9, 2007 PMCID 1978355
  • Weaver, T.E.  Adherence to positive airway pressure therapy.  Current Opinion in Pulmonary Medicine. 12(6):409-13, 2007. 
  • Hackney JE, Weaver, TE, Pack AI.  Health literacy and sleep disorders: A Review.  Sleep Medicine Reviews, 12(2):143-151, 2008 (Invited)  PMID:18222098
  • Weaver, TE, Grunstein R.  Adherence to continuous positive airway pressure therapy: The challenge to effective treatment. Proceedings of the American Thoracic Society, 5(2):173-178, 2008  PMID:18250209
  • Ye, L. & Weaver, T.E. Gender differences in obstructive sleep apnea and treatment response to continuous positive airway pressure.  Journal of Clinical Sleep Medicine, 2009
  • Weaver, T.E., Chasens E.R., Arora, S.  Modafinil improves functional outcomes in patients with residual excessive sleepiness associated with CPAP treatment Journal of Clinical Sleep Medicine 2009
  • Rodway, G.W., Weaver, T.E., Mancini, C., Cater, J., Maislin, G., Staley, B., Ferguson, K.A., George, C.F.P., Schulman, D.A., Greenberg, H., Rapoport, D.M., Walsleben, J.A., Lee-Chong, T., Kuna, S.T. Evaluation of sham-CPAP as a placebo in CPAP intervention studies.  SLEEP 33 (02), 260-266, 2010
  • Sawyer, A.M., Deatrick, J.A., Kuna, S.T., Weaver, TE.  Differences in perceptions of the diagnosis and treatment of obstructive sleep apnea and continuous positive airway pressure therapy among adherers and nonadherers.  Qualitative Health Research, 20(7): 873-892, 2010.
  • Reishtein, JL, Maislin, G, Weaver, TE and the Multisite Study Group.  Outcome of CPAP treatment on intimate and sexual relationships in obstructive sleep apnea.  Journal of Clinical Sleep Medicine, 6(3):221-226, 2010
  • Grandner, M.A., Patel, N.P., Gehrman, P.R., Xie, D., Sha, D., Weaver, TE., Gooneratne, N. Who gets the best sleep? Ethnic and socioeconomic factors related to sleep complaints. Sleep Medicine,11:470-8, 2010.
  • Weaver, T. E., Sawyer, A. M. Adherence to Continuous Positive Airway Pressure Treatment for Obstructive Sleep Apnea:  Current State of the Science and Implications for Future Intervention Research.  Indian Journal of Medical Research, 131: 245-258, 2010.
  • Prasad B, Choi YK, Weaver TE, Carley DW.  Pupillometric assessment of sleepiness in narcolepsy.  Frontiers in Psychiatry, 2 (35):1-7, 2011
  • Weaver, TE, Mancini C, Maislin G, Cater, J, Staley B, Landis JR, Ferguson KA, George CFP, Schulman DA, Greenberg H, Rapoport DM, Walsleben JA, Lee-Chiong T, Gurubhagavatula I, Kuna ST.  Continuous positive airway pressure treatment of sleepy patients with milder obstructive sleep apnea.  Results of the CPAP Apnea Trial North American Program (CATNAP) Randomized Clinical Trial.  Am J Resp Crit Care Med, 186(7):677-683, 2012.
  • Ye L,Pack AI, Maislin G, Dinges D, Hurley S, McCloskey S; Weaver TE.   Predictors of continuous positive airway pressure use during the first week of treatment.  J Sleep Res, 21(4):419-426, 2012
Current Research
  • Weaver, T.E. (Principal Investigator) (2009-2013). Mechanisms of Residual Sleepiness in CPAP Treated OSA Patients.  Investigator Initiated, Cephalon Corporation, $669,947.
  • Richards, K, Detra JA, Gooneratne NS, Hanlon, A, Hofmann, MT, Johnson JC, Moelter ST, Onen, F, Sawyer, AM, Sullivan-Marx, E,  Weaver, T.E. (Co-Investigator), Yushkevich PA,  (2011-2014) Obstructive sleep apnea and mild cognitive impairment. National Institute of Health, National Institute on Aging (R01-AG034682), $2,324,700.00