Impact of sleep apnea exacerbation on brain cholinergic signaling and cognition

Principal Investigator: Irina Topchiy

Dates:  9/15/16 - 8/31/18

Co-Investigators:  Irina Topchiy, David Carley, Michael Ragozzino

Abstract:   The current project is built on the basis of our R01 proposal aimed to determine how acute exacerbation of spontaneous sleep-related apnea perturbs brain cholinergic (ACh) signaling, contributing to impaired cognitive functioning. In this one-year R56 project we will collect key additional preliminary data to overcome important reviewer concerns, yielding a maximally competitive amended R01 application.

National Heart Lung and Blood Institute